![]() To address the questions raised by Unal Gulsuner et al., we investigated the role of the p.G399S substitution in 204 Parkinson disease and 103 essential tremor patients from Western Norway, including a population-based incident cohort of Parkinson disease patients and controls (the ParkWest study) ( 4). The authors discuss whether this discrepancy may be explained if the p.G399S substitution had a causal role in essential tremor and in the subset of Parkinson disease preceded by essential tremor. The p.G399S substitution has not been found more frequent in Parkinson disease patients than in control individuals ( 1– 3). Two heterozygous carriers were found among 364 Turkish controls. ![]() The p.G399S substitution was not found in further Parkinson disease or essential tremor patients. Additionally, parkinsonism developed in five affected family members, after age 70 in heterozygotes and in middle age in homozygotes. The p.G399S substitution was found in both heterozygous and homozygous states, and the number of copies correlated with earlier age of onset and more severe tremor in homozygous individuals. ![]() ( 1) report that a variant in the HtrA serine peptidase 2 ( HTRA2) gene caused essential tremor in a large consanguineous Turkish family. Continued abuse of our services will cause your IP address to be blocked indefinitely.Unal Gulsuner et al. Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. Overusing our search engine with a very large number of searches in a very short amount of time.Using a badly configured (or badly written) browser add-on for blocking content.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection.Using a script or add-on that scans GameFAQs for box and screen images (such as an emulator front-end), while overloading our search engine.There is no official GameFAQs app, and we do not support nor have any contact with the makers of these unofficial apps. Continued use of these apps may cause your IP to be blocked indefinitely. This triggers our anti-spambot measures, which are designed to stop automated systems from flooding the site with traffic. Some unofficial phone apps appear to be using GameFAQs as a back-end, but they do not behave like a real web browser does.Using GameFAQs regularly with these browsers can cause temporary and even permanent IP blocks due to these additional requests. If you are using Maxthon or Brave as a browser, or have installed the Ghostery add-on, you should know that these programs send extra traffic to our servers for every page on the site that you browse. ![]() The most common causes of this issue are: Your IP address has been temporarily blocked due to a large number of HTTP requests. ![]()
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